Spybot - Search & Destroy can detect and remove spyware of different kinds from your computer. Spyware is a relatively new kind of threat that common anti-virus applications do not yet cover. If you see new toolbars in your Internet Explorer that you didn't intentionally install, if your browser crashes, or if you browser start page has changed without your knowing, you most probably have spyware. But even if you don't see anything, you may be infected, because more and more spyware is emerging that is silently tracking your surfing behaviour to create a marketing profile of you that will be sold to advertisement companies. Spybot-S&D is free, so there's no harm in trying to see if something snooped into your computer, too :)If SpyBot-S&D finds such modules, it can remove them - or replace them with empty dummies in case their host software won't run with its bot removed. In most cases, the host still runs fine after removing the bot. For a list of 'supported' bots see the feature lists below. The Spybot-S&D interface is so easy, that updates just require replacing a file of about 80k in size. Those updates are distributed by my software mailinglist, at the authors page and are also available from inside the programs update section.Another feature of Spybot S&D is the removal of usage tracks, which makes it more complicated for unknown spybots to transmit useful data. The list of last visited websites, opened files, started programs, cookies, all that and more can be cleaned. Supported are the three major browsers Internet Explorer, Netscape Communicator and Opera.
Ashampoo Antivirus v1.6 is one of the newest and fastest anti-virus in town. Here is a 184 days of free Ashampoo Antivirus promo offer otherwise for which you have to pay. Many may not be aware or if aware, might not have used it. Well,6 months of free offer is lot of time to test with. Grab this chance quickly. Ashampoo offers many free softwares of its older edition. 
Avira AntiVir Windows Professional was designed to be a comprehensive, easy to use antivirus program, that will offer reliable virus protection to business users worldwide. Avira AntiVirus reliably protects you against all threats from viruses, worms, trojans, rootkits, phishings, adware, spyware, bots, and dangerous drive-by downloads. Best detection rates and top-class security with several updates every day.
Symantec's Norton AntiVirus 2009 - Winning protection against viruses, spyware, and other malicious threats! Heuristically detects Spyware threats, detects blocks Internet worm attacks, and protects email.Norton AntiVirus blocks viruses and spyware with advanced protection. It helps protect your entire computer by stopping viruses, spyware, and other security risks. Norton AntiVirus works in the background so you can surf the Internet, read the news, play games, and download software or music without disruption. It also scans and cleans all email and instant messaging (IM) attachments, preventing you from receiving viruses, or spreading them to others. 
Unlike other security solutions, which rely heavily on a list of pre-existing viruses, BitDefender security solutions use proactive B-HAVE technology that identifies and blocks new and zero-day threats. Additionally, BitDefender Total Security 2009 System’s maintenance and backup tools keep PCs running at optimal speed and protected from data loss.
The Avira Premium Security Suite protects you in a very comprehensive way against the dangers from the Internet. It offers you numerous advantages over the virus protection offered in the AntiVir Premium Edition. In addition to AntiVir, the Suite offers an integrated firewall that wards off attacks such as DoS attacks (Denial of Service attacks) or port scans and spam filtering to help you manage the complex attacks on your mail box.
NOD32 provides well balanced, state-of-the-art protection against threats endangering your PC and enterprise systems running various platforms from Microsoft Windows through a number of UNIX/Linux, Novell, MS DOS operating systems to Microsoft Exchange Server, Lotus Domino and other mail servers.
Quick Heal Total Security 2009 gives you complete protection from viruses, spywares, and hackers. It also helps you stay connected and communicate over the internet by preventing your system from threats over the Internet. With Quick Heal Total Security in your PC - Enjoy your freedom to work and play in the connected world.
Kaspersky Internet Security 8.0 – is a new line of Kaspersky Labs products, which is designed for the multi-tiered protection of personal computers. This product is based on in-house protection components, which are based on variety of technologies for maximum levels of user protection regardless of technical competencies. This product utilizes several technologies, which were jointly developed by Kaspersky Labs and other companies; part of them is implemented via online-services.
Agnitum Outpost Security Suite - a robust combination of award-winning firewall, fast and effective anti-malware, personalized antispam and proactive Host Protection module to defend against the majority of Internet risks. Includes automated configuration service and other user aids.
All-inclusive, comprehensive protection avast! 4 Professional Edition includes ANTI-SPYWARE protection, certified by the West Coast Labs Checkmark process, to protect against the latest spyware threats and ANTI-ROOTKIT DETECTION based on the best-in class GMER technology, built into the scan engine.